What is the best way to collision a high poly 3D model?

The best way to handle collision for a high poly 3D model is to use a simplified low-poly collision proxy that mirrors the high poly’s overall shape. This keeps real-time performance smooth (high poly has too many polygons for fast collision checks) while ensuring collisions feel accurate to the detailed model—critical for games, VR, or interactive apps. In Blender, simplify the high poly via decimation or draw a low-poly shape; in Unity/Unreal, assign the proxy as the "collider" component instead of the high poly.