For using Photoshop with node-based UV maps of 3D models, the best method combines its texturing tools with dedicated node UV editors (like Blender or RizomUV), since Photoshop lacks native node UV support.
Node UV tasks (e.g., unwrapping, adjusting seams via nodes) are handled in specialized tools—export the UV layout to Photoshop, where you can use its layers and brushes for detailed texture painting. This lets you keep the node UV workflow while leveraging Photoshop’s texturing strengths.
If starting out, use Blender’s free node UV tools to prepare your model’s UVs, then import the layout into Photoshop for texturing—this accessible combo covers both node UV editing and high-quality texturing.